- PO dose:
- 3-5mcg/kg (IBW) given 1-2 hours preop
- IV dose:
- Give 1.5mcg/kg (IBW) on induction, following incision if a sympathetic response is detected give additional 1.5mcg/kg
- Total dose 3mcg/kg, may give up to 5mcg/kg (increased SE and sedation)
- Dose may be given over 30 minutes in preop
- Long half life up to 18 hours with both PO and IV dose