• PO dose:
    • 3-5mcg/kg (IBW) given 1-2 hours preop
      • Bioavailbility is 75-95%
  • IV dose:
    • Give 1.5mcg/kg (IBW) on induction, following incision if a sympathetic response is detected give additional 1.5mcg/kg
      • Total dose 3mcg/kg, may give up to 5mcg/kg (increased SE and sedation)
      • Dose may be given over 30 minutes in preop
  • Long half life up to 18 hours with both PO and IV dose