McLott Mix

The McLott Mix is a combination of 4 medications that is administered to decrease or prevent the incidence of peripheral and central sensitization. McLott Mix is composed of Dexmedetomidine, Ketamine, Magnesium, and Lidocaine.

Infusion Rates

  • Lidocaine 2mg/kg/hr, Ketamine 0.3mg/kg/hr, Magnesium 10mg/kg/hr, Dexmedetomidine 0.4mcg/kg/hr
  • Infuse at 0.5ml/kg/hr (IBW or AdjBW)
  • Run infusion until closure begins

How to prepare in 50mL Syringe

  • Lidocaine 200mg
  • Ketamine 30mg
  • Magnesium 1gm
  • Dexmedetomidine 40mcg
  • Fill syringe with IV fluid for total volume of 50m
  • Larger infusion may be made in 100mL by doubling the amount of medications listed above, and removing corresponding volume from 100mL bag prior to injeciton of McLott Mix medication mixture